Fundamentals of Electrochemical, Aptameric-based Sensors

Abstract: 

Recognition methodologies for electrochemical sensing of specific analytes have been developing over many years. Creating specificity over similar analytes has been a goal, as often similar shaped molecules can bind to the sensor alongside the targeted analyte.  

One of the cutting-edge ways to enable targeted electrochemical sensing is to use single strand DNA or RNA molecules, also known as aptamers, as the biorecognition elements (BRE).

This seminar will provide insights into: 

• Overview of strategies for Biomolecular Sensing
• Electrochemical based sensing
  • Optical based methods
    • Plasmonic resonance energy transfer (PRET)
    • Nanoparticle surface energy transfer (NEST)
    • Surface plasmon resonance (SERS) biosensors
• Aptameric based sensing – key design elements to target analytes displayed in recent literature
  • Surface binding/functionalization approaches
  • Reporter/redox molecules to facilitate signal generation
  • BRE molecular structure dynamics

The seminar will be useful for the many researchers reviewing methods for effectively and reliably identifying science-based biomarkers for a wide range of diagnoses and reporting requirements for integration into products with a wide range of consumer and healthcare uses.

About the Featured Speaker

Jack Ly is a Program Manager and Research Scientist at UES, Inc. He received his PhD in Polymer Science and Engineering from the University of Massachusetts Amherst in 2018. At UES, Inc, he supports the Air Force Research Lab in designing, fabricating, and validating specialty polymers and analyte sensing chromophores for optical sensors. Most recent relevant published work involves fabrication of implantable, degradable phosphorescent O2 sensors.